Hyojung Choo

Hyojung Choo 's profile picture
hyojung.choo@emory.edu
Assistant Professor
Phone
404-727-3727
Office
542 Whitehead Research Building, Emory School of Medicine
Additional Research

"Craniofacial muscles are essential muscles for normal daily life. They are involved in facial expressions (facial muscles), blinking and eye movement (eye muscles), as well as speaking and eating (tongue and pharyngeal muscles). Interestingly, craniofacial muscles have differential susceptibility to several muscular dystrophies. For example, craniofacial muscles are the most affected muscles in oculopharyngeal muscular dystrophy but the least affected muscles in Duchenne muscular dystrophy. Among craniofacial muscles, dysfunction of tongue and pharyngeal muscles could cause an eating disability, called dysphagia, afflicts almost 15 million Americans including elderly, neuronal (Parkinson's disease and bulbar-onset amyotrophic lateral sclerosis) and muscular disease (oculopharyngeal muscular dystrophy) patients. However, no cure or therapeutic treatment exists for dysphagia caused by muscular dystrophy. Elucidation of the mechanism(s) behind these differing susceptibilities of craniofacial muscles could lead to development of potential therapeutics targeted to specific skeletal muscles involved in particular types of muscular dystrophy. The mechanisms of skeletal muscles are of interest here because skeletal muscle cells are multinucleated cells. Typically, skeletal muscle cells contain hundreds of nuclei in a single cell since they are generated by fusion of muscle precursor cells during development or by fusion of muscle specific stem cells, called satellite cells, in adult skeletal muscles. However, it is unclear how skeletal muscle cells regulate the quantity and quality of these multi-nuclei. Since craniofacial skeletal muscles, such as extraocular and pharyngeal muscles, have active satellite cell fusion in comparison to limb muscles, they are therefore suitable models to study myonuclear addition and homeostasis."

IRI/Group and Role
Bioengineering and Bioscience > Faculty
Bioengineering and Bioscience
Matter and Systems > Affiliated Faculty
University, College, and School/Department
Emory University
Research Areas
Matter and Systems
  • Human-Centric Technologies

Hannah Choi

Hannah Choi's profile picture
hannahch@gatech.edu

Hannah Choi is an Assistant Professor in the School of Mathematics at Georgia Tech. Her research focuses on mathematical approaches to neuroscience, with primary interests in linking structures, dynamics, and computation in data-driven brain networks at multiple scales. Before coming to Georgia Tech, she was a postdoctoral fellow at the University of Washington and also a visiting scientist at the Allen Institute for Brain Science, and spent one semester at the Simons Institute for the Theory of Computing at the University of California, Berkeley as a Patrick J McGovern Research Fellow. She received her Ph.D. in Applied Mathematics from Northwestern University and her BA in Applied Mathematics from the University of California, Berkeley.

Assistant Professor
IRI/Group and Role
Bioengineering and Bioscience > Faculty
Data Engineering and Science > Affiliated Faculty
Data Engineering and Science
Bioengineering and Bioscience
University, College, and School/Department
Georgia Institute of Technology > College of Sciences > School of Mathematics
Research Areas
Artificial Intelligence

Hee Cheol Cho

Hee Cheol Cho's profile picture
HeeCheol.Cho@emory.edu

Hee Cheol Cho is the Urowsky-Sahr Scholar in Pediatric Bioengineering and Associate Professor in the Department of Biomedical Engineering and Pediatrics. He received his PhD in Physiology from the University of Toronto in 2003.

Associate Professor
Urowsky-Sahr Scholar in Pediatric Bioengineering
Phone
404-727-6356
Office
Emory HSRB E184
Additional Research
The Heart Regeneration Lab focuses on using genes and chemicals to pace and regenerate the heart. We are based at Emory University in Pediatrics and BME in the Wallace H. Coulter Department of Biomedical Engineering of Georgia Tech and Emory University.
IRI/Group and Role
Bioengineering and Bioscience > Faculty
Bioengineering and Bioscience
University, College, and School/Department
Georgia Institute of Technology > College of Engineering > Coulter Department of Biomedical Engineering

Yury Chernoff

Yury Chernoff's profile picture
yury.chernoff@biology.gatech.edu

Yury O. Chernoff is a professor in the School of Biology and Institute for Bioengineering and Bioscience and Editor-in-Chief of the scientific journal Prion. He received his undergraduate and graduate training and Ph.D. degree in biology from St. Petersburg (then Leningrad) State University (Russia) and performed postdoctoral research at Okayama University (Japan) and University of Illinois at Chicago. 

Major topics of Dr. Chernoff’s research include yeast models for the protein aggregation disorders with an emphasis on the cellular control of protein aggregation and prion propagation, sequence-specificity of amyloid formation, and evolution of prion properties. 

Dr. Chernoff’s work provided the first experimental evidence for the chaperone role in prion phenomena.

Professor
Director, Center for Nanobiology of the Macromolecular Assembly Disorders (NanoMAD)
Phone
404-894-1157
Office
EBB 5016
Additional Research
Yeast genetics and molecular biology, chaperones and protein misfolding, amyloid and prion diseases, epigenetics and protein-based inheritance. Mylaboratory employsyeast models to studyprionsandamyloids.Prionswere initially identified as proteins in an unusual conformation that cause infectiousneurodegenerativediseases, such as "mad cow" disease,kuruorCreutzfeldt-Jakobdisease. Infection depends on theprion'sability to convert anon-prionprotein, encoded by the same host maintenance gene, into theprionconformation.Prionsform ordered cross-beta fibrous aggregates, termed amyloids. A variety of human diseases, includingAlzheimer'sdisease, are associated with amyloids and possess at least someprionproperties. Someamyloidshave positive biological functions. Manyproteins can formamyloidsin specific conditions. It is thought thatamyloidrepresents one of the ancient types of the protein fold. Some yeastnon-Mendelianheritable elements are based on aprionmechanism. This shows that heritable information can be coded in protein structures, in addition to information coded in DNA sequence. Therefore,prionsprovide a basis for the protein-based inheritance in yeast (and possibly in other organisms). Major topics of research in my lab include cellular control of prion formation and propagation (with a specific emphasis on the role of chaperone proteins), and development of the yeast models forstudying mammalian and humanamyloids, involved in diseases.Our research has demonstrated thatprionscan be induced by transient protein overproduction and discovered the crucial role of chaperones inprionpropagation, shown evolutionary conservation ofprion-formingproperties, established a yeast system for studying species-specificity ofpriontransmission,and uncovered links between prions,cytoskeletalnetworks and protein quality control pathways.
IRI/Group and Role
Bioengineering and Bioscience > Faculty
Bioengineering and Bioscience
University, College, and School/Department
Georgia Institute of Technology > College of Sciences > School of Biological Sciences

Lily Cheung

Lily Cheung's profile picture
lily.cheung@gatech.edu

Lily Cheung got her research start as a sophomore at Rutgers University, where she graduated Summa Cum Laude with a B.S. in Chemical Engineering in 2008. She then earned her Ph.D. in Chemical Engineering from Princeton University in 2013. Under the supervision of Stanislav Shvartsman, she characterized gene regulatory networks controlling the development of the model organism Drosophila melanogaster, using a combination of molecular biology, genetics, and reaction-diffusion modeling.

During her postdoctoral training with Wolf Frommer at the Carnegie Institution for Science, she designed biomolecular sensors to quantify sugar transport in plants. Her current interests include the use of high-throughput quantitative techniques and mathematical modeling to advance our understanding of how metabolic and gene regulatory networks interact to control plant growth.

Lily is the recipient of a NSF NPGI Postdoctoral Fellowship in Biology, a NSF CAREER Award, and a Human Frontier Science Program Early Career Award.

Assistant Professor
Phone
404-894-2826
Office
ES&T L1230
Additional Research

Engineering of genetically encoded biosensors Quantitative fluorescence microscopy and image analysis Computational models of gene regulatory networks Transcriptional regulation and developmental biology of plants The past fifteen years has seen dramatic advancements in genome sequencing and editing. The cost of sequencing a genome has decreased by two orders of magnitude, giving rise to new systems-level approaches to biology research that aim to understand life as an emerging property of all the molecular interactions in an organism. At the same time, technologies that allow site-specific modifications of the genome are enabling researchers to manipulate multicellular organisms in unprecedented ways. From reductionist approaches to systems biology, and from conventional plant breeding to synthetic biology, the future of plant biology research relies on the adoption of computational methods to analyze experimental data and develop predictive models. In biomedicine, mathematical models are already revolutionizing drug discovery; in agriculture, they have the potential to generate more efficient, faster growing crop varieties. The goal of the Cheung lab is to bring quantitative techniques and mathematical modeling to plants in order to gain systems-level insight into their physiology and development - particularly to understanding how metabolic and gene regulatory networks interact to control homeostasis and growth.

IRI/Group and Role
Bioengineering and Bioscience > Faculty
Renewable Bioproducts > Affiliated Faculty
Bioengineering and Bioscience
University, College, and School/Department
Georgia Institute of Technology > College of Engineering > School of Chemical and Biomolecular Engineering
Research Areas
Renewable Bioproducts
  • Science and Engineering of Natural Feedstocks

Yue Chen

Yue Chen's profile picture
yue.chen@bme.gatech.edu

Yue Chen is an assistant professor in the Department of Biomedical Engineering, GT/Emory. He received his Ph.D. degree in Mechanical Engineering from Vanderbilt University, M.S. in Mechanical Engineering from Hong Kong Polytechnic University, and a B.S. in Vehicle Engineering from Hunan University. His research focused on designing, modeling, and control of continuum robots and apply them in medicine.

Assistant Professor; Department of Biomedical Engineering at Georgia Tech & Emory
Phone
404.894.5586
Office
UAW4105
IRI/Group and Role
Bioengineering and Bioscience > Faculty
Robotics > Core
Robotics
Bioengineering and Bioscience
University, College, and School/Department
Georgia Institute of Technology
Research Areas
Artificial Intelligence

Young-Hui Chang

Young-Hui Chang's profile picture
yh.chang@ap.gatech.edu

Young-Hui Chang is a professor in the School of Biological Sciences, Associate Dean of Faculty for College of Sciences, and director of research in the Georgia Tech Comparative Neuromechanics Lab where he studies the neuromechanics of movement in humans and other animals. Chang’s aim is to understand fundamental principles by which we control our movements as we move through our physical environment. This requires knowledge of the neural control of movement, the biomechanics of our musculoskeletal system, and the physics of our environmental interactions. The team also studies how our body adapts to acute and chronic changes. This involves processes of motor learning that are involved in everything from clinical rehabilitation to elite sports performance.

Professor
Phone
404-894-9993
Office
1309 B
Additional Research

Biomechanics

Neural signaling

Neuromechanics

IRI/Group and Role
Bioengineering and Bioscience > Faculty
Bioengineering and Bioscience
Robotics > Core Faculty
University, College, and School/Department
Georgia Institute of Technology > College of Sciences > School of Biological Sciences
Research Areas
Robotics
  • Field and Service Robotics
  • Human-Centered Robotics
  • Safe, Secure, and Resilient Autonomy
  • Sensing and Perception
  • Manipulation and Locomotion

Leslie Chan

Leslie Chan's profile picture
leslie.chan@gatech.edu

Dr. Leslie Chan is an Assistant Professor in the Wallace H. Coulter Department of Biomedical Engineering at the Georgia Tech School of Engineering and Emory School of Medicine. Her research program integrates core and emerging principles from drug delivery, biomaterials development, and chemical biology to engineer diagnostic and therapeutic solutions for infectious disease, microbiome dysbiosis, and inflammatory diseases. Dr. Chan earned her B.S. in Biomedical Engineering from Georgia Tech and her Ph.D. in Bioengineering from the University of Washington with Professor Suzie Pun. She completed her postdoctoral training at Massachusetts Institute of Technology with Professor Sangeeta Bhatia. Dr. Chan is the recipient of an NIH K99/R00 Pathway to Independence Award.

Assistant Professor
Office
IBB 1314
Additional Research
Smart Materials, Infectious Disease, Microbiome, Inflammation
IRI/Group and Role
Bioengineering and Bioscience > Faculty
Bioengineering and Bioscience
University, College, and School/Department
Georgia Institute of Technology > College of Engineering > Coulter Department of Biomedical Engineering

Julie Champion

Julie Champion's profile picture
julie.champion@chbe.gatech.edu

Julie Champion is the William R. McLain Endowed Term Professor in the School of Chemical and Biomolecular Engineering at Georgia Institute of Technology. She earned her B.S.E. in chemical engineering from the University of Michigan and Ph.D. in chemical engineering at the University of California Santa Barbara. She was an NIH postdoctoral fellow at the California Institute of Technology. Champion is a fellow of the American Institute for Medical and Biological Engineering and has received awards including American Chemical Society Women Chemists Committee Rising Star, NSF BRIGE Award, Georgia Tech Women in Engineering Faculty Award for Excellence in Teaching, Georgia Tech BioEngineering Program Outstanding Advisor Award. Professor Champion’s current research focuses on design and self-assembly of functional nanomaterials made from engineered proteins for applications in immunology, cancer, and biocatalysis.

Professor, School Chemical and Biomolecular Engineering
Phone
404.894.2874
Office
EBB 5015
Additional Research

Cellular Materials; Drug Delivery; Self-Assembly; "Developing therapeutic protein materials, where the protein is both the drug and thedelivery system Engineering proteins to control and understand protein particleself-assembly Repurposing and engineering pathogenic proteins for human therapeutics Creating materials that mimic cell-cell interactions to modulate immunologicalfunctions for various applications, including inflammation, cancer, autoimmune disease, and vaccination"

IRI/Group and Role
Bioengineering and Bioscience > Faculty
Matter and Systems > Affiliated Faculty
Bioengineering and Bioscience
University, College, and School/Department
Georgia Institute of Technology > College of Engineering > School of Chemical and Biomolecular Engineering
Research Areas
Matter and Systems
  • Computing and Communication Technologies
  • Human-Centric Technologies

Vince Calhoun

Vince Calhoun's profile picture
vcalhoun@gatech.edu

Vince Calhoun, Ph.D., is the founding director of the tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) where he holds appointments at Georgia State, Georgia Tech and Emory. He is the author of more than 900 full journal articles. His work includes the development of flexible methods to analyze neuroimaging data including blind source separation, deep learning, multimodal fusion and genomics, neuroinformatics tools. Calhoun is a fellow of the Institute of Electrical and Electronic Engineers, The American Association for the Advancement of Science, The American Institute of Biomedical and Medical Engineers, The American College of Neuropsychopharmacology, The Organization for Human Brain Mapping (OHBM) and the International Society of Magnetic Resonance in Medicine. He currently serves on the IEEE BISP Technical Committee and is also a member of IEEE Data Science Initiative Steering Committee as well as the IEEE Brain Technical Committee.

Director TReNDS
Director CABI
Distinguished University Professor
IRI/Group and Role
Bioengineering and Bioscience > Faculty
Bioengineering and Bioscience
Research Areas
Artificial Intelligence
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