Julien Meaud joined Georgia Tech as an Assistant Professor of Mechanical Engineering in August 2013. Before joining Georgia Tech, he worked as a research fellow in the Vibrations and Acoustics Laboratory and in the Computational Mechanics Laboratory at the University of Michigan, Ann Arbor. 

Dr. Meaud investigates the mechanics and physics of complex biological systems and the mechanics and design of engineering materials using theoretical and computational tools. 

One of his research interests is auditory mechanics. In this research, he develops computational multiphysics models of the mammalian ear based on the finite element method. The mammalian ear is a nonlinear transducer with excellent frequency selectivity, high sensitivity, and good transient capture. The goal of this basic scientific research is to better understand how the mammalian ear achieves these characteristics. This research could have important clinical applications as it could help in the development of better treatment and the improvement of diagnostic tools for hearing loss. It could also have engineering applications, such as the design of biometic sensors. This research is truly interdisciplinary as it includes aspects of computational mechanics, structural acoustics, nonlinear dynamics, biomechanics and biophysics. 

Dr. Meaud is also interested in the mechanics, design and optimization of composite materials, particularly of their response to cyclic loads. Tradtional engineering and natural materials with high damping (such as rubber) tends to have low stiffness. However, the microarchitecture of composite materials that consist of a lossy polymer and a stiff constituent can be designed to simultaneously obtain high stiffness and high damping. Using computational tools such as finite element methods and topology optimization, the goal of Dr. Meaud's research is to design composite materials with these unconventional properties. One of his future goal is to extend the design of these materials to the finite strain regime and high frequency ranges, in order to obtained materials tailored for the targetted application. This research includes aspects of mechanics of materials, computational mechanics and structural dynamics. 

In Dr. Meaud's research group, students will learn theoretical and computational techniques that are used extensively to solve engineering problems in academic research and industry. Students will develop knowledge and expertise in a broad array of mechanical engineering areas. The knowledge that students will gain in computational mechanics, nonlinear and structural dynamics, structural acoustics, dynamics and composite materials could be applied to many domains in their future career.

Patrick McGrath's research group is interested in understanding the genetic basis of heritable behavioral variation. In the current age, it has become cheap and easy to catalog the set of genetic differences between two individuals. But which genetic differences are responsible for generating differences in innate behaviors, including liability to neurological diseases such as autism, bipolar disease, and schizophrenia? How do these causative genetic variants modify a nervous system? Besides their role in disease, genetic variation is the substrate for natural selection. To understand how behavior evolves, we must understand how it varies.

In the McCarty lab, we focus on the molecular physiology of ion channels and receptors, with emphasis on epithelial chloride channels. Our specific focus is the pathophysiology of Cystic Fibrosis, including the structure/function of CFTR and its many roles in the airway. We pioneered the use of peptide toxins as probes of chloride channels. We also have projects that study the functional consequences of heterodimerization among GPCRs, the role of CFTR in regulation of sweat composition, and the molecular ecology of predator-prey interactions in the marine environment. Our translational research in CF targets: (a) the mechanism by which the expression of mutant CFTR in airway epithelial cells impacts the development of CF-related diabetes; and (b) identification of biomarkers of acute pulmonary exacerbations in CF along with development of a novel device for their detection in the home. 

The goal of the Center for Cystic Fibrosis Research is to engage Atlanta researchers in basic and translational research that will lead to a better understanding of the pathophysiology of this disease and/or generate new devices and treatments to increase the length and quality of life for CF patients. The novel theme for these research activities is 'The Systems Biology of the CF Lung'.

Hang Lu received her B.S. from the University of Illinois, Urbana-Champaign and her M.S.C.E.P and Ph.D. from the Massachusetts Institute of Technology. She is currently the Associate Dean for Research and Innovation in the College of Engineering and C. J. "Pete" Silas Chair, School of Chemical & Biomolecular Engineering at the Georgia Institute of Technology. Lu's research interests involve the interface of engineering and biology and her lab, the Lu Fluidics Group, is conducting research at these interface levels. The Lu Fluidics Group engineers BioMEMS (Bio Micro-Electro-Mechanical System) and microfluidic devices to address questions in neuroscience, cell biology, and biotechnology that are difficult to answer using conventional techniques.

Faces of Research - Profile Article

Dr. Gabe Kwong is an Assistant Professor in the Wallace H. Coulter Department of Biomedical Engineering at the Georgia Tech School of Engineering and Emory School of Medicine. His research program is conducted at the interface of the life sciences, medicine and engineering where a central focus is understanding how to harness the sophisticated defense mechanisms of immune cells to eradicate disease and provide protective immunity. Kwong has pioneered numerous biomedical technologies and published in leading scientific journals such as Nature Biotechnology and Nature Medicine. His work has been profiled broadly including coverage in The Economist, NPR, BBC, and WGBH-2, Boston 's PBS station. Professor Kwong earned his B.S. in Bioengineering with Highest Honors from the University of California, Berkeley and his Ph.D. in Bioengineering from California Institute of Technology with Professor James R. Heath. He conducted postdoctoral studies at Massachusetts Institute of Technology with Professor Sangeeta N. Bhatia. For his work, Dr. Kwong has been awarded the NIH Ruth L. Kirschstein National Research Service Award, named a "Future Leader in Cancer Research and Translational Medicine" by the Massachusetts General Hospital, and awarded the Burroughs Wellcome Fund Career Award at the Scientific Interface, a distinction given to the 10 most innovative bioengineers in the nation. Dr. Kwong holds seven issued or pending patents in cancer nanotechnology.

Julia Kubanek serves as Georgia Tech’s Vice President for Interdisciplinary Research and is a professor in the School of Biological Sciences and the School of Chemistry and Biochemistry. In this role, she oversees and supports interdisciplinary activities at Georgia Tech including the Interdisciplinary Research Institutes (IRIs); the Pediatric Technology Center (PTC), the Novelis Innovation Hub; the Center for Advanced Brain Imaging (CABI); and the Global Center for Medical Innovation (GCMI). She also partners across the institute on developing and advancing new research initiatives based on student and faculty interests, expertise, and societal need.

Kubanek has held several previous leadership roles at Georgia Tech, including Associate Dean for Research in the College of Sciences and Associate Chair in the School of Biological Sciences. She joined the faculty at Georgia Tech in 2001. Her areas of research interest include chemical signaling among organisms (especially in aquatic systems), natural products chemistry, metabolomics, chemical biology, and drug discovery. She has authored approximately 100 research articles on marine plankton and coral reef chemical ecology, and on the discovery, mechanism of action, and biosynthesis of marine natural products. She was awarded the NSF CAREER Award in 2002, the Presidential Early Career Award for Scientists and Engineers (PECASE) in 2004, and was elected Fellow of the American Association for the Advancement of Science (AAAS) in 2012. In 2016, she served as chair of the Gordon Research Conference in Marine Natural Products; since 2016, she has chaired the Scientific Advisory Board of the Max Planck Institute for Chemical Ecology. Kubanek received her B.Sc. in Chemistry from Queen’s University, Canada, in 1991 and her Ph.D. in at the University of British Columbia in 1998, and performed postdoctoral research at the University of California – San Diego and the University of North Carolina at Wilmington.

Selected recent publications:

➤ Robert G. Mannino, Eric J. Nehl, Sarah Farmer, Amanda Foster Peagler, Maren C. Parsell, Viviana Claveria, David Ku, David S. Gottfried, Hang Chen, Wilbur A. Lam, and Oliver Brand, “The critical role of engineering in the rapid development of COVID-19 diagnostics: Lessons from the RADx Tech Test Verification Core” Science Advances. 9, eade4962 (2023). https://www.science.org/doi/10.1126/sciadv.ade4962

➤ Liu ZL, Bresette C, Aidun CK, Ku DN. (2021) SIPA in 10 milliseconds: VWF tentacles agglomerate and capture platelets under high shear. Blood Advances doi.org/10.1182/bloodadvances.2021005692

➤ Kim DJ, Ku DN. “Structure of shear-induced platelet aggregated clot formed in an in vitro arterial thrombosis model” Blood Adv (2022) 6 (9): 2872–2883. doi.org/10.1182/bloodadvances.2021006248

➤ Kim DJ, Bressette C, Liu Z, Ku DN. Occlusive thrombosis in arteries.  APL Bioengineering  2019;3, 041502. https://doi.org/10.1063/1.5115554

Licensed Patents: 

➤ Ku, D.N., Wootton, D.M., Greer-Braddon, L., “Poly(vinyl Alcohol) Cryogel,” No. 5,981,826 and 6,231,605, issued May 15, 2001. Licensed; created prosthetic cartilage; acquired by Wright Medical. $645 million

➤ Denoziere, G., Ku, D.N., “Methods of Producing PVA Hydrogel Implants and Related Devices,” issued U.S. Patent No. 8,038,920, Licensed to Mimedx.  Market cap >$600 million.

Dr. Kostka is currently a professor of Biology at Georgia Institute of Technology (GT). Prior to GT, he was an Associate Professor at the Department of Oceanography, Florida State University. His research involves microorganism studies in geochemical cycles of pristine and contaminated ecosystems, from the oceans to the terrestrial subsurface.

Dr. Kostas Konstantinidis joined the Georgia Institute of Technology as an Assistant Professor in November 2007. He received his BS in Agriculture Sciences from the Aristotle University of Thessaloniki (Greece) in 1999. He continued his studies at the Center for Microbial Ecology at Michigan State University (East Lansing, MI) under the supervision of Prof. James M. Tiedje, where he obtained a PhD in 2004. His PhD studies were fully supported by the Bouyoukos Fellowship program and were devoted in advancing our understanding of the ecology and physiology of soil bacteria through the comparative analysis of their whole-genome sequences. This research resulted in a NSF-funded project to advance the species definition for prokaryotes, which also fostered a short post-doc position at the Center for Microbial Ecology. He then moved to MIT and the laboratory of Prof. Edward DeLong to get trained on innovating metagenomic techniques. His work at MIT provided important new insights into the complexity and function of oceanic microbial communities as well as how life is adapting in the deep and cold Oceans. His research interests are at the interface of genomics and computational biology in the context of microbial ecology with the overarching goal to broaden understanding of the genetic and metabolic potential of the microbial world. Advancing our knowledge on these issues is essential for a better understanding of the microbes that power, by and large, the biogeochemical cycles that sustain life on Earth and cause or control important diseases in humans and animals. He is a member of the American Society for Microbiology (ASM), the International Society for Microbial Ecology (ISME) and the Association of Environmental Engineering and Science Professors (AEESP). Konstantinidis held the Carlton S. Wilder Junior Professorship for five years and subsequently received the Maulding Faculty Fellowship in the School of Civil and Environmental Engineering.

Melissa Lambeth Kemp received her B.S. in Nuclear Engineering from MIT and her Ph.D. in Bioengineering from University of Washington. Dr. Kemp joined the faculty at Georgia Tech in 2006 after completing postdoctoral training at MIT. Her expertise is in computational modeling of metabolism and signal transduction, as well as developing statistical modeling tools to examine network relationships in high-dimension datasets. One major aspect of her research program linking ROS – the byproducts of aerobic metabolism – to the fundamental way that cells interpret instructions from their environment, their neighbors, and their own genetic blueprint. Specific applications of her diverse work include systems modeling of transient phosphatase oxidation of kinase cascades, patient-specific differences in cytotoxicity to redox-cycled chemotherapeutics and radiation, and the coordination of oxidative metabolism with epithelial-to-mesenchymal transition. Her research program also includes a component of developing high-throughput screening methods for assaying cue-signal-response relationships in cells and analytical tools for single cell gene expression. 

Dr. Kemp currently serves as the Research Director of the multi-site NSF Engineering Research Center “Cell Manufacturing Technologies”. In her former role as Associate Director of the NSF Science and Technology Center “Emergent Behavior of Integrated Cellular Systems”, she spearheaded the multi-site center’s computational activities by developing agent-based models of context-dependent cellular decisions to generate new hypotheses of intercellular communication in pluripotent stem cell differentiation and emergent patterning; this work continues currently in quantifying organizational principles and spatial relationships in iPSC-derived tissues from multi-omics data. Dr. Kemp’s career honors include a Whitaker Graduate Fellowship, Merck/CSBi postdoctoral fellowship, Georgia Cancer Coalition Distinguished Scholar, NIH New Innovator Award, and the CSB2 Prize for Innovative Measurement Methods from the Council for Systems Biology in Boston.