Will Gutekunst

Will Gutekunst
willgute@gatech.edu

The Gutekunst Lab is interested in pushing the limits of complexity in macromolecular systems using innovative concepts from synthetic organic chemistry. 

Specific projects in the lab will explore the design of novel monomers for the construction of functional polyamides, the development of small molecule reagents for the dynamic modulation of branched polymer architectures, and the investigation of new concepts for creating covalent bonds in challenging contexts. Each of these research projects will enable the generation of new functional materials with structures or assemblies that were previously inaccessible for study. 

Prospective students will obtain extensive training in synthetic organic chemistry, as well as polymer synthesis and characterization.

Associate Professor
RBI Co-Lead: Interface of polymer science and wood-based materials
Phone
404-894-4675
Office
MoSE 1100Q
IRI and Role
Renewable Bioproducts > Faculty
Renewable Bioproducts > Leadership
Renewable Bioproducts
Matter and Systems > Affiliated Faculty
University, College, and School/Department
Georgia Institute of Technology > College of Sciences > School of Chemistry & Biochemistry
Research Areas
Matter and Systems
  • Computing and Communication Technologies

Neha Garg

Neha Garg
neha.garg@chemistry.gatech.edu

Professor Garg received a Bachelors in Engineering in Biotechnology from University Institute of Technology and Masters in Science from Indian Institute of Technology, Delhi. During her masters, she spent several months in Berlin, Germany while conducting research with Professor Marion Ansorge Schumacher at Technical University, Berlin as an DAAD Fellow. Garg obtained her Ph.D. in 2013 from the University of Illinois, Urbana Champaign under the direction of Professor Wilfred A. van der Donk and Professor Satish Nair. She then joined Professor Pieter C Dorrestein's research laboratory as a postdoctoral research associate at the University of California, San Diego. Garg joined the faculty at GeorgiaTech in 2017.

Associate Professor
Phone
404-385-5677
Office
EBB 4016
Additional Research
Eukaryotes, including humans, are 'petri dishes', hosting an abundant and a rich prokaryotic 'microbiome'. The Garg Lab aims to understand the molecular interactions between a eukaryotic host and its microbiome, and how these molecular interactions dictate human health and disease. Using a concoction of innovative tools including bioinformatics, clinical microbiology, mass spectrometry, DNA sequencing, and mass spectrometry-based 2D and 3D spatial imaging, we aim to delineate specific molecules that modulate the dynamics of microbial involvement in our response to genetic and environmental triggers of disease. We characterize the biosynthesis of these small molecule natural products to innovate developement of new therapeutics.
IRI and Role
Bioengineering and Bioscience > Faculty
Bioengineering and Bioscience
University, College, and School/Department
Georgia Institute of Technology > College of Sciences > School of Chemistry & Biochemistry

Stefan France

Stefan France
stefan.france@chemistry.gatech.edu

Stefan France is an Associate Professor in the School of Chemistry and Biochemistry. Professor France earned his B.S. in Chemistry (2000) from Duke University and a M.A. (2003) and Ph.D. (2005) in Organic Chemistry from Johns Hopkins University. His research group focuses on experimental methodology development, natural product synthesis, and medicinal chemistry. Owing to Prof. France's avid interest in undergraduate research, his research group has mentored and trained more than 60 undergraduates (both Georgia Tech and non-Georgia Tech students). Professor France has been the recipient of several awards for his research, mentorship, and teaching including: the 2018 Georgia Tech-Georgia Power Professor of Excellence; the 2015 Georgia Tech Senior Faculty Outstanding Undergraduate Mentor Award; the 2014 Georgia Tech Faculty Award for Academic Outreach; the 2014 Georgia Tech Hesberg Teaching Award; the 2013 Georgia Tech Sigma Xi Young Faculty Award; the 2012 National Organization for the Professional Advancement for Black Chemists and Chemical Engineers (NOBCChE) Lloyd N. Ferguson Young Scientist Award; and the 2011 National Science Foundation (NSF) CAREER Award. He heads the Chemistry FAST Program, a NSF Research Experiences for Undergraduates (REU) Site, and also serves as Chair of the NSF Chemistry REU Leadership Group.

Associate Professor
Phone
404-385-1796
Office
MoSE 2100K
Additional Research
Our group is interested in the design of efficient methodologies to accomplish the formation of carbon-carbon and carbon-heteroatom bonds with the intent to apply the methodology toward the synthesis of complex natural and unnatural targets. Natural Product Synthesis. Approaches to natural products not only inspire the development of new synthetic strategies, but often unveil unexpected and often interesting reactivity. Targets are chosen for their interesting biological activity along with their sheer complexity. We are interested in exploring both modular and convergent approaches to complex targets that enable facile derivatization for the development of combinatorial libraries. Medicinal Chemistry. Medicinal or pharmaceutical chemistry lies at the intersection of chemistry and pharmacy. Our group is interested in the design, synthesis and development of pharmaceutical drugs, or other chemical entities suitable for therapeutic use. We are further interested in the study of their biological properties and their quantitative structure-activity relationships (QSAR). Given that medicinal chemistry is a highly interdisciplinary science, we aim to establish several collaborations with biologists, biochemists, and computational chemists to facilitate the design and development process. In particular, we aim to develop therapeutics toward the treatment of various forms of cancer, HIV, diabetes, and neurological disorders, such as Alzheimer's and Parkinson's disease.
IRI and Role
Bioengineering and Bioscience > Faculty
Renewable Bioproducts > Faculty
Bioengineering and Bioscience
Renewable Bioproducts
University, College, and School/Department
Georgia Institute of Technology > College of Sciences > School of Chemistry & Biochemistry

M.G. Finn

mgfinn@gatech.edu
Professor, James A. Carlos Family Chair for Pediatric Technology
Phone
404-385-0906
Office
MoSE 2201B
Additional Research

We develop chemical and biological tools for research in a wide range of fields. Some of them are briefly described below; please see our group web page for more details. Chemistry, biology, immunology, and evolution with viruses. The sizes and properties of virus particles put them at the interface between the worlds of chemistry and biology. We use techniques from both fields to tailor these particles for applications to cell targeting, diagnostics, vaccine development, catalysis, and materials self-assembly. This work involves combinations of small-molecule and polymer synthesis, bioconjugation, molecular biology, protein design, protein evolution, bioanalytical chemistry, enzymology, physiology, and immunology. It is an exciting training ground for modern molecular scientists and engineers. Development of reactions for organic synthesis, chemical biology, and materials science. Molecular function is what matters most to our scientific lives, and good chemical reactions provide the means to achieve such function. We continue our efforts to develop and optimize reactions that meet the click chemistry standard for power and generality. Our current focus is on highly reliable reversible reactions, which open up new possibilities for polymer synthesis and modification, as well as for the controlled delivery of therapeutic and diagnostic agents to biological targets. Traditional and combinatorial synthesis of biologically active compounds.We have a longstanding interest in the development of biologically active small molecules. We work closely with industrial and academic collaborators on such targets as antiviral agents, compounds to combat tobacco addiction, and treatments for inflammatory disease.

IRI and Role
Bioengineering and Bioscience > Faculty
Data Engineering and Science > Affiliated Faculty
Data Engineering and Science
Bioengineering and Bioscience
University, College, and School/Department
Georgia Institute of Technology > College of Sciences > School of Chemistry & Biochemistry

Facundo Fernandez

Facundo Fernandez
facundo.fernandez@chemistry.gatech.edu

Facundo was born in Buenos Aires, Argentina. He received his MSc in Chemistry from the College of Exact and Natural Sciences, Buenos Aires University in 1995 and his PhD in Analytical Chemistry from the same University, in 1999.  In August 2000, he joined the research group of Prof. Richard N. Zare in the Department of Chemistry at Stanford University.  His work focused on several aspects of Hadamard transform time-of-flight mass spectrometry with an emphasis on coupling this technique to capillary-format separation methods.  In 2002, he joined the group of Prof. Vicki Wysocki in the Department of Chemistry at the University of Arizona, to develop novel tandem mass spectrometers for gas-phase peptide ion studies. In 2004 he joined the School of Chemistry and Biochemistry at the Georgia Institute of Technology where he currently holds the position of Vasser-Woolley Endowed Professor in Bioanalytical Chemistry and Associate Chair for Research and Graduate Training. He is the author of over 185 peer-reviewed publications and numerous invited presentations at national and international conferences. He has received several awards, including the NSF CAREER award, the CETL/BP Teaching award, the Ron A. Hites best paper award from the American Society for Mass Spectrometry, and the Beynon award from Rapid Communications in Mass Spectrometry, among others. He serves on the editorial board of The Analyst and as an Associate editor for the Journal of the American Society for Mass Spectrometry. His current research interests include the field of metabolomics and the development of new ionization, imaging, machine learning and ion mobility spectrometry tools for probing composition and structure in complex molecular mixtures. In his (limited) free time, Facundo enjoys a number of activities that include camping with his family, rock climbing, paddling, archery, photography and ham radio. 

Vasser Woolley Foundation Chair in Bioanalytical Chemistry
Professor; School of Chemistry and Biochemistry
Phone
404.385.4432
Office
ES&T L1244
Additional Research
Mass Spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of biological molecules embedded in complex matrices. Although MS has found widespread use, improvements are still needed to extend its application to the grand challenges of this century. Since starting my position at Georgia Tech in 2004, my group members and I have used an integrated strategy with roots in bioanalytical chemistry, instrumentation development, bioinformatics, and theoretical modeling to focus on questions of great societal and scientific significance. To this purpose, we have integrated with cross-cutting teams devoted to problems that range from explaining the origins of life on Earth and diagnosing cancer at an early stage, to tracking the sources and prevalence of counterfeit pharmaceuticals worldwide. The common theme along these questions is the need for highly accurate tools for quantifying, identifying, and imaging trace chemicals in complex mixtures. Research in our lab uses state-of-the-art mass spectrometry, ion mobility gas-phase separations,ultrahigh performance liquid chromatography, and new soft ion generation techniques. We investigate the obtained data using machine learning and other powerful bioinformatic approaches. Our group is very dynamic, and each student pursues more than one project at a time, usually in collaboration with other group members or with other research groups at GT or elsewhere. Graduate and undergraduate students are trained in a variety of bioanalytical instrumentation/methodologies, with an emphasis on the fundamentals. We are analytical mass spectrometrists at heart, and strive to answer "big" scientific questions or questions with a large societal impact.
IRI and Role
Bioengineering and Bioscience > Faculty
Data Engineering and Science > Faculty
Bioengineering and Bioscience
University, College, and School/Department
Georgia Institute of Technology > College of Sciences > School of Chemistry & Biochemistry

Christoph Fahrni

Christoph Fahrni
fahrni@chemistry.gatech.edu

Christoph Fahrni earned a master’s degree in chemistry from the Federal Institute of Technology (ETH, Switzerland) and a Ph.D. degree in chemistry from the University of Basel (Switzerland). After working as a postdoctoral fellow at Northwestern University (Evanston, IL), he joined the School of Chemistry and Biochemistry at the Georgia Institute of Technology in 1999.

Professor
Associate Chair for Graduate and Postdoctoral Programs
Phone
404-385-1164
Office
Petit Biotechnology Building, Office 3310
Additional Research
Metals In Biological Systems. Approximately one third of all known proteins contain metal ions as cofactors and serve a wide variety of functions, such as structure stabilization, catalysis, electron transfer reactions or complex tasks, including signal transduction and gene regulation. Numerous diseases such as haemochromatosis or Menkes disease were found to be related with a defect in metal metabolism. Research is concerned with development of metal specific fluorescent probes for the investigation of the intracellular chemistry of trace elements, the mechanistic study of metalloprotein catalyzed reactions with unusual coordination geometries as well as the development of protein-based, semisynthetic organometallic catalysts in aqueous solution. Fluorescence Probes and Chelators for the Investigation of Intracellular Storage, Trafficking, and Homeostasis of Trace Elements. Until recently, little was known about how eukaryotic cells take up metal ions or regulate intracellular concentrations. Fluorescent chemosensors have been proven to be powerful and nondestructive tools for the study of intracellular metal ion distributions and have provided a wealth of information, including control of muscle contraction, nerve cell communication, hormone secretion, and immune cell activation. Research is concerned with the development of highly specific fluorescent probes for the detailed mechanistic investigation of copper storage and trafficking. Distribution and changes of intracellular copper concentration can be followed in vivo using fluorescence microscopy. Various combinatorial fluorophore libraries are being synthesized, which subsequently are screened for copper binding selectivity. Bioorganometallic Catalysis with Peptide and Protein Ligands. The distribution of metal ions in sea water can be directly correlated with their abundance in biological systems. Consequently, the platinum metals palladium, rhodium, iridium and platinum are not found in any of the natural occurring metalloproteins. Nevertheless, these cations are excellent catalysts for a wide variety of organometallic reactions. Research is focused on combining the rich chemistry of platinum metals with the advantage of proteins to catalyze reactions with high regio- and stereo-selectivity. Novel bioorganometallic catalysts are being developed via redesign of structurally well characterized proteins.
IRI and Role
Bioengineering and Bioscience > Faculty
Bioengineering and Bioscience
University, College, and School/Department
Georgia Institute of Technology > College of Sciences > School of Chemistry & Biochemistry

Robert Dickson

Robert Dickson
robert.dickson@chemistry.gatech.edu

Dr. Dickson is the Vassar Woolley Professor of Chemistry & Biochemistry and has been at Georgia Tech since 1998. He was a Senior Editor of The Journal of Physical Chemistry from 2010-2021, and his research has been continuously funded (primarily from NIH) since 2000. Dr. Dickson has developed quantitative bio imaging and signal recovery/modulation schemes for improved imaging of biological processes and detection of medical pathologies. His work on fluorescent molecule development and photoswitching of green fluorescent proteins was recognized as a key paper for W.E. Moerner’s 2014 Nobel Prize in Chemistry. Recently, Dr. Dickson’s lab has developed rapid susceptibility testing of bacteria causing blood stream infections. Their rapid recovery methods, coupled with rigorous multidimensional statistics and machine learning have led to very simple, highly accurate and fast methods for determining the appropriate treatment within a few hours after positive blood cultures. These hold significant potential for drastically improving patient outcomes and reducing the proliferation of antimicrobial resistance.

Professor
Phone
404-894-4007
Office
MoSE G209A
Additional Research
Dr. Dickson's group is developing novel spectroscopic, statistical, and imagingtechnologies for the study of dynamics in biology and medicine.
IRI and Role
Bioengineering and Bioscience > Faculty
Data Engineering and Science > Affiliated Faculty
Data Engineering and Science
Bioengineering and Bioscience
University, College, and School/Department
Georgia Institute of Technology > College of Sciences > School of Chemistry & Biochemistry

Aditi Das

Aditi Das
aditi.das@chemistry.gatech.edu

Aditi Das did her BSc. (Hons.) Chemistry from St. Stephen's College Delhi, followed by M.S. (Chemistry) from I.I.T (Kanpur). She received her Ph.D. in Chemistry from Princeton University. She did post-doctoral work with Prof. Steve Sligar. She joined University of Illinois, Urbana-Champaign (UIUC) as a tenure track assistant professor in 2012. In 2019, she was promoted to associate professor with tenure. In 2022, she joined School of Chemistry and Biochemistry at Georgia Institute of Technology as an associate professor with tenure. Her research is in the area of enzymology of oxygenases that are involved lipid metabolism and cannabinoid metabolism.

Das is recipient of an American Heart Associate (AHA) career award and has been funded by National Institute of Health (NIH - NIGMS, NIDA and NCCIH), USDA, and National Multiple Sclerosis Society (NMSS). Her research was recognized by several National awards: Young Investigator award From Eicosanoid Research Foundation, Mary Swartz Rose Young Investigator Award and E.L.R. Stokstad award from American Society for Nutrition (ASN) for outstanding research on bioactive compounds for human health. She is also the recipient of Zoetis Research Excellence Award from her college. She was a co-organizer of the International Conference on Cytochrome P450. Recently her laboratory contributed several papers on cannabinoid metabolism by p450s. In recognition of this work, she was awarded El Sohly award from the ACS-Cannabis division for excellence in Cannabis research and is invited to give plenary lecture at ISSX meeting.  Das is also a standing study section member of BBM NIH study section. 

Associate Professor
Phone
609-203-6924
Office
3306 IBB
IRI and Role
Bioengineering and Bioscience > Faculty
Bioengineering and Bioscience
University, College, and School/Department
Georgia Institute of Technology > College of Sciences > School of Chemistry & Biochemistry

David Collard

David Collard
david.collard@cos.gatech.edu

The main focus of Collard's research is the molecular self-assembly in polymers which allows for the formation of new supermolecular architectures that take on new functions and promise potential benefits and novel applications. Currently, his group is studying surfactants, spontaneously assembled monolayers, and liquid crystals. Materials under study include conjugated electronically conductive polymers and new functional polyesters. Techniques used to construct and probe the structure of our supramolecular assemblies including: synthesis, electrochemistry, thermal analysis, X-ray diffraction and microscopy.

Professor, School of Chemistry and Biochemistry
Associate Dean, College of Sciences
Phone
404.894.4026
Additional Research

Conducting polymers, diffraction methods, functional co-polymers

IRI and Role
Data Engineering and Science > Affiliated Faculty
Data Engineering and Science
University, College, and School/Department
Georgia Institute of Technology > College of Sciences > School of Chemistry & Biochemistry

Marcus Cicerone

Marcus Cicerone
cicerone@gatech.edu

Marcus T Cicerone received his Ph.D. from the University of Wisconsin – Madison in 1994, under the direction of Mark Ediger. He spent three years at Johnson & Johnson Clinical Diagnostics, served as a visiting teaching professor at Brigham Young University for two years, and subsequently joined the National Institute of Standards and Technology in 2001, where he remained for 18 years, serving as a group leader and project leader. In January 2019 he joined the Georgia Institute of Technology as a Professor of Chemistry. 

Professor Cicerone is a fellow of American Physical Society, and has received several awards for his efforts in coherent Raman-based biological imaging and for his work in dynamics of liquids and amorphous solids. These include a Johnson & Johnson Director’s Research Award, two Department of Commerce Bronze metals, the 2015 Washington Academy of Sciences Physical & Biological Sciences Award, and the 2017 Arthur S. Flemming Award.

Professor
Phone
404-894-2761
Office
G026 MoSE
Additional Research
Professor Cicerone works on development and application of spectroscopic coherent Raman imaging approaches and on dynamics of amorphous condensed matter. In the coherent Raman imaging work, his group introduced broadband (spectroscopic) coherent anti-Stokes Raman scattering (BCARS) microscopy in 2004. Since then he and his group have remained at the forefront of this field, introducing improvements such as a time-domain Kramers-Kronig transform to deal with non-causal signals for retrieving the pure Raman spectrum directly from the raw BCARS signal. The results of that work and other instrument design innovations utilizing impulsive vibrational coherence generation resulted in recognition as one of the top 10 innovations in BioPhotonics for 2014. His group has logged many imaging firsts, including the first to obtain quantitative vibrational fingerprint spectra from mammalian cells using coherent Raman imaging, and the first to identify specific structural proteins from coherent Raman imaging.His work on dynamics of amorphous condensed matter focuses on the impact of picosecond timescale spatial and temporal heterogeneity in dynamics on transport and relaxation in liquids and glasses. In 2004, he used neutron scattering to show for the first time that chemical and physical stability of proteins encapsulated in glassy sugars could be predicted by the profile of ps-timescale dynamics. Since then, he has developed a framework for calculating transport and relaxation properties of liquids and glasses over 12 orders of magnitude in time, based solely on ps-timescale dynamics, and identified the molecular origin of a relaxation process (Johari-Goldstein process) that had been observed but remained enigmatic for 50 years. He has also developed benchtop approaches accessible to pharmaceutical labs for measuring the relevant dynamics, and developed a protein stability approach for drug delivery that encapsulates proteins in nanometer-sized droplets of vitrified sugar-based glass and makes them impervious to traditional processing steps, allowing retention of ~99% of protein function or titer after all processing steps. This approach has now been used successfully in large animal trials, and has also been shown to be effective for transdermal drug delivery due to the nanometer size of the encapsulation materials.
IRI and Role
Bioengineering and Bioscience > Faculty
Bioengineering and Bioscience
University, College, and School/Department
Georgia Institute of Technology > College of Sciences > School of Chemistry & Biochemistry