Candace Fleischer

Candace Fleischer
ccfleis@emory.edu

Candace C. Fleischer, PhD, is an Assistant Professor in the Department of Radiology and Imaging Sciences at the Emory University School of Medicine. Dr. Fleischer also holds a faculty appointment at the Wallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University. She serves as the director of the Biomedical Spectroscopy and Imaging Laboratory.

Dr. Fleischer is a spectroscopist with formal training in physical chemistry and biomedical engineering. Her research group is highly collaborative and focused on the development of new MR spectroscopy and imaging technologies for biomedical and translational applications. 

Current projects include the development of magnetic resonance-based methods for identifying inflammatory biomarkers in malignant brain tumors; and creating new tools for non-invasively measuring brain temperature with applications in cerebrovascular and cardiovascular injury. Her laboratory is also committed to community outreach and increasing scientific literacy.

Assistant Professor of Radiology and Imaging Sciences, Emory University
Assistant Professor of Biomedical Engineering, Georgia Tech and Emory University
IRI/Group and Role
Bioengineering and Bioscience > Faculty
Bioengineering and Bioscience
University, College, and School/Department
Emory University > Department of Radiology and Imaging Sciences

M.G. Finn

mgfinn@gatech.edu
Professor, James A. Carlos Family Chair for Pediatric Technology
Phone
404-385-0906
Office
MoSE 2201B
Additional Research

We develop chemical and biological tools for research in a wide range of fields. Some of them are briefly described below; please see our group web page for more details. Chemistry, biology, immunology, and evolution with viruses. The sizes and properties of virus particles put them at the interface between the worlds of chemistry and biology. We use techniques from both fields to tailor these particles for applications to cell targeting, diagnostics, vaccine development, catalysis, and materials self-assembly. This work involves combinations of small-molecule and polymer synthesis, bioconjugation, molecular biology, protein design, protein evolution, bioanalytical chemistry, enzymology, physiology, and immunology. It is an exciting training ground for modern molecular scientists and engineers. Development of reactions for organic synthesis, chemical biology, and materials science. Molecular function is what matters most to our scientific lives, and good chemical reactions provide the means to achieve such function. We continue our efforts to develop and optimize reactions that meet the click chemistry standard for power and generality. Our current focus is on highly reliable reversible reactions, which open up new possibilities for polymer synthesis and modification, as well as for the controlled delivery of therapeutic and diagnostic agents to biological targets. Traditional and combinatorial synthesis of biologically active compounds.We have a longstanding interest in the development of biologically active small molecules. We work closely with industrial and academic collaborators on such targets as antiviral agents, compounds to combat tobacco addiction, and treatments for inflammatory disease.

IRI/Group and Role
Bioengineering and Bioscience > Faculty
Bioengineering and Bioscience
University, College, and School/Department
Georgia Institute of Technology > College of Sciences > School of Chemistry & Biochemistry

Alberto Fernandez-Nieves

Alberto Fernandez-Nieves
afn3@gatech.edu

Soft materials are materials whose properties are determined by internal structures with dimensions between atomic sizes and macroscopic scales. They are characterized by energies that are typically comparable to kT. As a result, they have low elastic moduli, often ~1-10 Pascals. Typical soft materials include liquid crystals, polymers, colloidal suspensions and emulsion drops. These materials, unlike conventional simple liquids, are locally heterogeneous and can have broken symmetries that affect their physical properties. Hence, although they often exhibit liquid-like behavior, soft materials also often exhibit properties of solids. Our laboratory studies the physics of soft materials with a focus on the connection between microscopic order and macroscopic properties. The underlying theme is to pursue basic understanding and address fundamental questions. However, we also address applied problems and pursue industrial collaborations since many of the materials we study can be viewed as model systems for those that are often used in applications. Current projects include (i) studying the phase and non-equilibrium behavior and properties of dense microgel suspensions, (ii) understanding the consequences of confinement and curvature over the equilibrium states of ordered materials, which in many cases require the existence of topological defects in their ground states, and (iii) electrohydrodynamics of toroidal droplets and jets.

Associate Professor, School of Physics
Director, Soft Condensed Matter Laboratory
Phone
404.385.3667
Office
Boggs B19
Additional Research

Physics of soft materials with a focus on the connection between microscopic order and macroscopic properties, hydrodynamics, advanced characterization, polymers, computational mechanics

IRI/Group and Role
Bioengineering and Bioscience > Faculty
Bioengineering and Bioscience
University, College, and School/Department
Georgia Institute of Technology > College of Sciences

Facundo Fernandez

Facundo Fernandez
facundo.fernandez@chemistry.gatech.edu

Facundo was born in Buenos Aires, Argentina. He received his MSc in Chemistry from the College of Exact and Natural Sciences, Buenos Aires University in 1995 and his PhD in Analytical Chemistry from the same University, in 1999.  In August 2000, he joined the research group of Prof. Richard N. Zare in the Department of Chemistry at Stanford University.  His work focused on several aspects of Hadamard transform time-of-flight mass spectrometry with an emphasis on coupling this technique to capillary-format separation methods.  In 2002, he joined the group of Prof. Vicki Wysocki in the Department of Chemistry at the University of Arizona, to develop novel tandem mass spectrometers for gas-phase peptide ion studies. In 2004 he joined the School of Chemistry and Biochemistry at the Georgia Institute of Technology where he currently holds the position of Vasser-Woolley Endowed Professor in Bioanalytical Chemistry and Associate Chair for Research and Graduate Training. He is the author of over 185 peer-reviewed publications and numerous invited presentations at national and international conferences. He has received several awards, including the NSF CAREER award, the CETL/BP Teaching award, the Ron A. Hites best paper award from the American Society for Mass Spectrometry, and the Beynon award from Rapid Communications in Mass Spectrometry, among others. He serves on the editorial board of The Analyst and as an Associate editor for the Journal of the American Society for Mass Spectrometry. His current research interests include the field of metabolomics and the development of new ionization, imaging, machine learning and ion mobility spectrometry tools for probing composition and structure in complex molecular mixtures. In his (limited) free time, Facundo enjoys a number of activities that include camping with his family, rock climbing, paddling, archery, photography and ham radio. 

Vasser Woolley Foundation Chair in Bioanalytical Chemistry
Professor; School of Chemistry and Biochemistry
Phone
404.385.4432
Office
ES&T L1244
Additional Research
Mass Spectrometry (MS) is one of the key analytical methods used to identify and characterize small quantities of biological molecules embedded in complex matrices. Although MS has found widespread use, improvements are still needed to extend its application to the grand challenges of this century. Since starting my position at Georgia Tech in 2004, my group members and I have used an integrated strategy with roots in bioanalytical chemistry, instrumentation development, bioinformatics, and theoretical modeling to focus on questions of great societal and scientific significance. To this purpose, we have integrated with cross-cutting teams devoted to problems that range from explaining the origins of life on Earth and diagnosing cancer at an early stage, to tracking the sources and prevalence of counterfeit pharmaceuticals worldwide. The common theme along these questions is the need for highly accurate tools for quantifying, identifying, and imaging trace chemicals in complex mixtures. Research in our lab uses state-of-the-art mass spectrometry, ion mobility gas-phase separations,ultrahigh performance liquid chromatography, and new soft ion generation techniques. We investigate the obtained data using machine learning and other powerful bioinformatic approaches. Our group is very dynamic, and each student pursues more than one project at a time, usually in collaboration with other group members or with other research groups at GT or elsewhere. Graduate and undergraduate students are trained in a variety of bioanalytical instrumentation/methodologies, with an emphasis on the fundamentals. We are analytical mass spectrometrists at heart, and strive to answer "big" scientific questions or questions with a large societal impact.
IRI/Group and Role
Bioengineering and Bioscience > Faculty
Data Engineering and Science > Faculty
Bioengineering and Bioscience
University, College, and School/Department
Georgia Institute of Technology > College of Sciences > School of Chemistry & Biochemistry

Flavio Fenton

Flavio Fenton
flavio.fenton@physics.gatech.edu

My work is on excitable media, complex systems, and pattern formation, using a combined approach of theory, experiments, and computer simulations.

Interested in: Complex Systems, Experimental physiology, Biophysics, High performance computing and GPU.

Professor
Phone
516-672-6003
Office
Howey N05
Additional Research
  • Bioinformatics
  • High Performance Computing
IRI/Group and Role
Bioengineering and Bioscience > Faculty
Data Engineering and Science > Affiliated Faculty
Data Engineering and Science
Bioengineering and Bioscience
University, College, and School/Department
Georgia Institute of Technology > College of Sciences > School of Physics

Andrei Fedorov

Andrei Fedorov
AGF@gatech.edu

Fedorov's background is in thermal/fluid sciences, chemical reaction engineering as well as in applied mathematics. His laboratory works at the intersection between mechanical and chemical engineering and solid state physics and analytical chemistry with the focus on portable/ distributed power generation with synergetic CO2 capture; thermal management of high power dissipation devices and electronics cooling; special surfaces and nanostructured interfaces for catalysis, heat and moisture management; and development of novel bioanalytical instrumentation and chemical sensors. Fedorov joined Georgia Tech in 2000 as an assistant professor after finishing his postdoctoral work at Purdue University.

Professor and Rae S. and Frank H. Neely Chair, Woodruff School Mechanical Engineering
Associate Chair for Graduate Studies, School Mechanical Engineering
Director, Fedorov Lab
Phone
404.385.1356
Office
Love 307
Additional Research

Heat Transfer; power generation; CO2 Capture; Catalysis; fuel cells; "Fedorov's research is at the interface of basic sciences and engineering. His research portfolio is diverse, covering the areas of portable/ distributed power generation with synergetic carbon dioxide management, including hydrogen/CO2 separation/capture and energy storage, novel approaches to nanomanufacturing (see Figure), microdevices (MEMS) and instrumentation for biomedical research, and thermal management of high performance electronics. Fedorov's research includes experimental and theoretical components, as he seeks to develop innovative design solutions for the engineering systems whose optimal operation and enhanced functionality require fundamental understanding of thermal/fluid sciences. Applications of Fedorov's research range from fuel reformation and hydrogen generation for fuel cells to cooling of computer chips, from lab-on-a-chip microarrays for high throughput biomedical analysis to mechanosensing and biochemical imaging of biological membranes on nanoscale. The graduate and undergraduate students working with Fedorov's lab have a unique opportunity to develop skills in a number of disciplines in addition to traditional thermal/fluid sciences because of the highly interdisciplinary nature of their thesis research. Most students take courses and perform experimental and theoretical research in chemical engineering and applied physics. Acquired knowledge and skills are essential to starting and developing a successful career in academia as well as in many industries ranging from automotive, petrochemical and manufacturing to electronics to bioanalytical instrumentation and MEMS."

IRI/Group and Role
Bioengineering and Bioscience > Faculty
Energy > Hydrogen Group
Energy > Research Community
Bioengineering and Bioscience
Energy
University, College, and School/Department
Georgia Institute of Technology > College of Engineering > Woodruff School of Mechanical Engineering
Research Areas
Energy
  • Energy Storage
  • Nuclear
  • Carbon Capture, Utilization and Storage

Yuhong Fan

Yuhong Fan
yuhong.fan@biology.gatech.edu
Associate Professor
Georgia Research Alliance Distinguished Scholar
Phone
404-385-1312
Office
Petit Biotechnology Building, Office 2313
Additional Research
  • Bioinformatics
  • Chromatin
  • Epigenetics,  Epigenomics & Epidrugs
  • Gene Expression
  • Stem Cell Biology
  • Stem Cell Differentiation
IRI/Group and Role
Bioengineering and Bioscience > Faculty
Data Engineering and Science > Faculty
Data Engineering and Science
Bioengineering and Bioscience
University, College, and School/Department
Georgia Institute of Technology > College of Sciences > School of Biological Sciences

Christoph Fahrni

Christoph Fahrni
fahrni@chemistry.gatech.edu

Christoph Fahrni earned a master’s degree in chemistry from the Federal Institute of Technology (ETH, Switzerland) and a Ph.D. degree in chemistry from the University of Basel (Switzerland). After working as a postdoctoral fellow at Northwestern University (Evanston, IL), he joined the School of Chemistry and Biochemistry at the Georgia Institute of Technology in 1999.

Professor
Associate Chair for Graduate and Postdoctoral Programs
Phone
404-385-1164
Office
Petit Biotechnology Building, Office 3310
Additional Research
Metals In Biological Systems. Approximately one third of all known proteins contain metal ions as cofactors and serve a wide variety of functions, such as structure stabilization, catalysis, electron transfer reactions or complex tasks, including signal transduction and gene regulation. Numerous diseases such as haemochromatosis or Menkes disease were found to be related with a defect in metal metabolism. Research is concerned with development of metal specific fluorescent probes for the investigation of the intracellular chemistry of trace elements, the mechanistic study of metalloprotein catalyzed reactions with unusual coordination geometries as well as the development of protein-based, semisynthetic organometallic catalysts in aqueous solution. Fluorescence Probes and Chelators for the Investigation of Intracellular Storage, Trafficking, and Homeostasis of Trace Elements. Until recently, little was known about how eukaryotic cells take up metal ions or regulate intracellular concentrations. Fluorescent chemosensors have been proven to be powerful and nondestructive tools for the study of intracellular metal ion distributions and have provided a wealth of information, including control of muscle contraction, nerve cell communication, hormone secretion, and immune cell activation. Research is concerned with the development of highly specific fluorescent probes for the detailed mechanistic investigation of copper storage and trafficking. Distribution and changes of intracellular copper concentration can be followed in vivo using fluorescence microscopy. Various combinatorial fluorophore libraries are being synthesized, which subsequently are screened for copper binding selectivity. Bioorganometallic Catalysis with Peptide and Protein Ligands. The distribution of metal ions in sea water can be directly correlated with their abundance in biological systems. Consequently, the platinum metals palladium, rhodium, iridium and platinum are not found in any of the natural occurring metalloproteins. Nevertheless, these cations are excellent catalysts for a wide variety of organometallic reactions. Research is focused on combining the rich chemistry of platinum metals with the advantage of proteins to catalyze reactions with high regio- and stereo-selectivity. Novel bioorganometallic catalysts are being developed via redesign of structurally well characterized proteins.
IRI/Group and Role
Bioengineering and Bioscience > Faculty
Bioengineering and Bioscience
University, College, and School/Department
Georgia Institute of Technology > College of Sciences > School of Chemistry & Biochemistry

C. Ross Ethier

C. Ross Ethier
ross.ethier@bme.gatech.edu

Prof. Ethier was originally trained as a mechanical engineer, receiving his Ph.D. from MIT in 1986 working in the lab of Roger D. Kamm. He then joined the University of Toronto, where he was a Professor of Bioengineering, Mechanical Engineering and Ophthalmology, and latterly the Director of the Institute of Biomaterials and Biomedical Engineering. Prior to joining Georgia Tech/Emory, Professor Ethier was the Head of the Department of Bioengineering at Imperial College, London from 2007-12. 

His research is in the biomechanics of cells and whole organs. His specific research topics include glaucoma (biomechanics of aqueous humour drainage in the normal and glaucomatous eye, and the mechanical and cellular response of optic nerve tissues to intraocular pressure), study of hemodynamic basis of arterial disease.

Professor
Georgia Research Alliance Lawrence L. Gellerstedt, Jr. Eminent Scholar in Bioengineering
Phone
404-385-0100
Office
Petit Biotechnology Building, Office 2306
Additional Research
"Biomechanics and mechanobiology, glaucoma, osteoarthritis, regenerative medicine, intraocular pressure control, optic nerve head biomechanics. We work at the boundaries between mechanics, cell biology and physiology to better understand the role of mechanics in disease, to repair diseased tissues, and to prevent mechanically-triggered damage to tissues and organs. Glaucoma is the second most common cause of blindness. We carry out a range of studies to understand and treat this disease. For example, we are developing a new, mechanically-based, strategy to protect fragile neural cells that, if successful, will prevent blindness. We are developing protocols for stem-cell based control of intraocular pressure. We study the mechanobiology and biomechanics of neurons and glial cells in the optic nerve head. We also study VIIP, a major ocular health concern in astronauts. Osteoarthritis is the most common cause of joint pain. We are developing paradigms based on magneto-mechanical stimulation to promote the differentiation and (appropriate) proliferation of mesenchymal stem cells."
IRI/Group and Role
Bioengineering and Bioscience > Faculty
Bioengineering and Bioscience
University, College, and School/Department
Georgia Institute of Technology > College of Engineering > Coulter Department of Biomedical Engineering