Michelle’s research is themed around designing and characterizing the surface chemical properties of synthetic and natural polymer systems. They will be used to develop multifunctional biomaterial substrates for regenerative medicine, cancer treatment, and personal care products. The goals of the Gaines Lab are achieved by marrying Polymer Synthesis, Materials Science, Cell Biology & Spectroscopy.

Faces of Research - Profile Article

Soft materials are materials whose properties are determined by internal structures with dimensions between atomic sizes and macroscopic scales. They are characterized by energies that are typically comparable to kT. As a result, they have low elastic moduli, often ~1-10 Pascals. Typical soft materials include liquid crystals, polymers, colloidal suspensions and emulsion drops. These materials, unlike conventional simple liquids, are locally heterogeneous and can have broken symmetries that affect their physical properties. Hence, although they often exhibit liquid-like behavior, soft materials also often exhibit properties of solids. Our laboratory studies the physics of soft materials with a focus on the connection between microscopic order and macroscopic properties. The underlying theme is to pursue basic understanding and address fundamental questions. However, we also address applied problems and pursue industrial collaborations since many of the materials we study can be viewed as model systems for those that are often used in applications. Current projects include (i) studying the phase and non-equilibrium behavior and properties of dense microgel suspensions, (ii) understanding the consequences of confinement and curvature over the equilibrium states of ordered materials, which in many cases require the existence of topological defects in their ground states, and (iii) electrohydrodynamics of toroidal droplets and jets.

Erik C. Dreaden joined the Wallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University in 2017. Dr. Dreaden also holds a joint faculty appointment in the Department of Pediatrics at the Emory University School of Medicine where he collaborates with researchers at Children's Healthcare of Atlanta and the Aflac Center for Cancer and Blood Disorders. Dr. Dreaden's research seeks to apply principles of molecular and nanoscale engineering to improve the therapeutic potential of drug combinations, vaccines, and immunotherapies directed against pediatric and adult cancers. 

Prior to joining Emory and Georgia Tech, Dr. Dreaden was a postdoctoral fellow at the Koch Institute for Integrative Cancer Research at MIT, where his research focused on the development of polymer-based technologies for nucleic acid and rational combination cancer therapies. 

Dr. Dreaden is a member of the Cancer Immunology Research Program at the Winship Cancer Institute of Emory University. He also holds memberships in the Biomedical Engineering Society, American Institute of Chemical Engineers, American Association of Cancer Research, Materials Research Society, American Association for the Advancement of Science, and American Chemical Society.

Dr. Simone Douglas-Green (@DrBlackBoots on Twitter/X and Instagram) is a new Assistant Professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, where she has been named a BME Distinguished Faculty Fellow. She received her B.S. in Biomedical Engineering from the University of Miami, and her Ph.D. in Biomedical Engineering from the joint program at Georgia Tech and Emory University. Dr. Douglas-Green’s professional and scholarly development as a doctoral and postdoctoral trainee has been supported by a number of awards including the Alfred P. Sloan Foundation's Minority Ph.D. (MPHD) Fellowship, NASEM Ford Foundation Postdoctoral Fellowship, and Burroughs Wellcome Fund Postdoctoral Enrichment Program (PDEP). The Douglas-Green Lab focuses on developing tools/techniques to study how biology interacts with nanoparticles with an emphasis on understanding person and disease specific proteins coronas. Her goal is to train the next generation of engineers to be “EPIC”- engineering with purpose, intentionality, and compassion.

Dr. Davis holds positions as a Professor in both Cardiology and Biomedical Engineering at the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University. Additionally, he serves as an associate chair for graduate studies at BME department, and a director of the Children's Heart Research and Outcomes (HeRO) Center. He received his Ph.D. in Molecular and Systems Pharmacology at Emory University in 2003 working on molecular regulation of eNOS expression by shear stress. From 2003-2006, he completed his postdoctoral fellowship at Brigham and Women's Hospital working on cardiac tissue engineering with collaborators at the Massachusetts Institute of Technology. He moved back to Emory in 2006 to join the faculty in Division of Cardiology and Biomedical Engineering Department.

Lakshmi Prasad Dasi is an established researcher in the field of prosthetic heart valves, cardiovascular biomechanics, biomaterials, and devices. He is currently a tenure Professor of Biomedical Engineering, at Georgia Institute of Technology while holding the Rozelle Vanda Wesley Endowed Professorship as well as being the Associate Chair for Undergraduate Studies. He has held positions at The Ohio State University, and Colorado State University previously. He is a Fellow of the American College of Cardiology (FACC) as well as Fellow of the American Institute for Medical and Biological Engineering (FAIMBE). 

Dasi earned his Ph.D. from Georgia Institute of Technology in 2004 with a focus in fluid dynamics and turbulence. He trained as a postdoctoral fellow and research engineer under Prof. Ajit Yoganathan’s mentorship at Georgia Tech where he transformed his research focus to heart valves, devices, and cardiovascular biomechanics. In 2009, he established the Cardiovascular Biofluid Mechanics Lab (CBFL) as Assistant Professor at Colorado State University and moved to The Ohio State University in 2015 as his focus became more translational. Since 2020, his research at Georgia Tech focuses on tackling the complexity of: (a) heart valve biomechanics (native and prosthetic); (b) prosthetic heart valve engineering (conventional & trans-catheter); (c) structure-function relationships of the heart in health and disease at the embryonic, pediatric, as well as adult stages; and (d) turbulence and turbulent blood flow.

James Dahlman is a bioengineer / molecular engineer whose work lies at the interface of chemistry, nanotechnology, genomics, and gene editing. His lab focuses on targeted drug delivery, in vivo gene editing, Cas9 therapies, siRNA therapies, and developing new technologies to improve biomaterial design. 

The DahlmanLab is known for applying 'big data' technologies to nanomedicine. The lab is pioneering DNA barcoded nanoparticles; using DNA barcodes, >200 nanoparticles can be analyzed simultaneously in vivo. These nanoparticles are studied directly in vivo, and used to deliver targeted therapies like siRNA, mRNA, or Cas9. As a result of this work, James was named 1 of the 35 most innovative people under the age of 35 by MIT Technnology Review in 2018. James has won many national / international awards, and has published in Science, Nature Nanotechnology, Nature Biotechnology, Nature Cell Biology, Cell, Science Translational Medicine, PNAS, JACS, ACS Nano, Nano Letters, and other journals. James has also designed nanoparticles that efficiently deliver RNAs to the lung and heart. These nanoparticles can deliver 5 siRNAs at once in vivo, and are under consideration for clinical development. As a result, the lab has an interest in immunology and vascular biology. 

James supports entirely new research students come up with independently. To this end, DahlmanLab students learn how to (i) generate new ideas, (ii) select the good ones, and (iii) efficiently test whether the good ideas will actually work. 

Dahlman Lab students learn how to design/characterize/administer nanoparticles, how to isolate different cell types in vivo, how to rationally design DNA to record information, Cas9 therapies, and deep sequencing. As a result, the lab is an interdisciplinary group with students that have backgrounds in medicinal chemistry, BME, bioinformatics, biochemistry, and other fields. The lab welcomes students with all types of scientific backgrounds. The lab firmly stands by students, independent of their personal beliefs, preferences, or backgrounds.

The Curtis lab is primarily focused on the physics of cell-cell and cell-extracellular matrix interactions, in particular within the context of glycobiology and immunobiology. Our newest projects focus on questions of collective and single cell migration in vitro and in vivo; immunophage therapy "an immunoengineering approach - that uses combined defense of immune cells plus viruses (phage) to overcome bacterial infections"; and the study of the molecular biophysics and biomaterials applications of the incredible enzyme, hyaluronan synthase. A few common scientific themes emerge frequently in our projects: biophysics at interfaces, the use of quantitative modeling, collective interactions of cells and/or molecules, cell mechanics, cell motility and adhesion, and in many cases, the role of bulky sugars in facilitating cell integration and rearrangements in tissues.