Raquel Lieberman

Raquel Lieberman's profile picture
raquel.lieberman@chemistry.gatech.edu

Raquel Lieberman is the Sepcic-Pfeil Professor of Chemistry and Biochemistry at Georgia Tech. Her research program focuses on the biophysical and structural characterization of proteins and on understanding how disease-associated mutations affect protein function or dysfunction (e.g., aggregation). Rooted in basic research, the long-term goal of her work is to translate mechanistic discoveries into disease-modifying therapies.

One major focus of her research is glaucoma-associated myocilin, a project that has been funded by the NIH since March 2011. Her lab has made significant progress toward a detailed molecular understanding of myocilin structure, function, and disease pathogenesis. This work has revealed similarities between myocilin-associated glaucoma and other protein misfolding disorders, particularly amyloid diseases. Collectively, these efforts are paving the way toward the first disease-modifying therapeutic for glaucoma.

Lieberman also has extensive experience in the study of membrane enzymes. During her thesis work, she solved the first crystal structure of the copper-dependent particulate methane monooxygenase. As a postdoctoral researcher, she shifted her focus to intramembrane aspartyl proteases (IAPs), particularly those involved in neurodegenerative diseases such as Alzheimer’s disease. In her independent laboratory, she developed new proteomics-based assays to measure IAP proteolysis. Her lab also collaborates with physicists at Oak Ridge National Laboratory to use neutron scattering to probe protein structure and lipids in solution. This work has been funded by both the NSF and NIH.

In addition to her research activities, Lieberman serves on the Executive Council of the Protein Society and as an academic editor for PLoS Biology. She is also co-PI of the Department of Education GAANN program in Biochemistry and Biophysics at Georgia Tech and serves on a variety of advisory committees.

Professor
Phone
404-385-3663
Office
Petit Biotechnology Building, Office 1308
Additional Research

The Lieberman research group focuses on biophysical and structural characterization of proteins involved in misfolding disorders. One major research project in the lab has been investigations of the glaucoma-associated myocilin protein. The lab has made major strides toward detailed molecular understanding of myocilin structure, function, and disease pathogenesis. Our research has clearly demonstrated similarities between myocilin glaucoma and other protein misfolding disorders, particularly amyloid diseases. The work has led to new efforts aimed at amelioratingthe misfolding phenotype using chemical biology approaches. Our second project involves the study of membrane-spanning proteolytic enzymes, which have been implicated disorders such as Alzheimer disease. Our group is tackling questions surrounding discrimination among and presentation of transmembrane substrates as well as the enzymatic details of peptide hydrolysis. In addition to the biochemical characterization of intramembrane aspartyl proteases, our group is developing new crystallographic tools to improve the likelihood of determining structures of similarly challenging membrane proteins more generally.

IRI/Group and Role
Bioengineering and Bioscience > Faculty
Bioengineering and Bioscience > Faculty Steering Committee
University, College, and School/Department
Georgia Institute of Technology > College of Sciences > School of Chemistry & Biochemistry
Research Areas
Renewable Bioproducts
  • Pulp, Paper, Packaging and Tissue
  • Circular Materials

Gabe Kwong

Gabe Kwong's profile picture
gkwong@gatech.edu

Dr. Gabe Kwong is a Professor in the Wallace H. Coulter Department of Biomedical Engineering at the Georgia Tech School of Engineering and Emory School of Medicine. His research program is conducted at the interface of the life sciences, medicine and engineering where a central focus is understanding how to harness the sophisticated defense mechanisms of immune cells to eradicate disease and provide protective immunity. Kwong has pioneered numerous biomedical technologies and published in leading scientific journals such as Nature Biotechnology and Nature Medicine. His work has been profiled broadly including coverage in The Economist, NPR, BBC, and WGBH-2, Boston 's PBS station. Professor Kwong earned his B.S. in Bioengineering with Highest Honors from the University of California, Berkeley and his Ph.D. in Bioengineering from California Institute of Technology with Professor James R. Heath. He conducted postdoctoral studies at Massachusetts Institute of Technology with Professor Sangeeta N. Bhatia. For his work, Dr. Kwong has been awarded the NIH Ruth L. Kirschstein National Research Service Award, named a "Future Leader in Cancer Research and Translational Medicine" by the Massachusetts General Hospital, and awarded the Burroughs Wellcome Fund Career Award at the Scientific Interface, a distinction given to the 10 most innovative bioengineers in the nation. Dr. Kwong holds seven issued or pending patents in cancer nanotechnology.

Professor
Director, Laboratory for Synthetic Immunity
Phone
404-385-3746
Office
Marcus Nanotechnology 3132
Additional Research

Human health has been transformed by our collective capacity to engineer immunity — from the pivotal development of the smallpox vaccine to the curative potential of recent cancer immunotherapies. These examples motivate our research program that is conducted at the interface of Engineering and Immunology, and where we develop biomedical technologies and applications that shape a diverse array of immunological systems.The questions that are central to our exploration include: How do we begin to study an individual's repertoire of well over one billion immune cells when current technologies only allow us to study a handful of cells at a time? What are the biomarkers of immunological health as the body responds to disease and ageing, and how may these indicators trigger clinical decisions? And how can we genetically rewire immune cells to provide them with entirely new functions to better fight complex diseases such as cancer?To aid in our studies, we use high-throughput technologies such as next-generation sequencing and quantitative mass spectrometry, and pioneer the development of micro- and nanotechnologies in order to achieve our goals. We focus on clinical problems in cancer, infectious diseases and autoimmunity, and ultimately strive to translate key findings into therapies for patients.

IRI/Group and Role
Bioengineering and Bioscience > Faculty
Bioengineering and Bioscience
Matter and Systems > Affiliated Faculty
University, College, and School/Department
Georgia Institute of Technology > College of Engineering > Coulter Department of Biomedical Engineering

Julia Kubanek

Julia Kubanek's profile picture
julia.kubanek@biosci.gatech.edu

Julia Kubanek serves as Georgia Tech’s Vice President for Interdisciplinary Research and is a professor in the School of Biological Sciences and the School of Chemistry and Biochemistry. In this role, she oversees and supports interdisciplinary activities at Georgia Tech including the Interdisciplinary Research Institutes (IRIs); the Pediatric Technology Center (PTC), the Novelis Innovation Hub; the Center for Advanced Brain Imaging (CABI); and the Global Center for Medical Innovation (GCMI). She also partners across the institute on developing and advancing new research initiatives based on student and faculty interests, expertise, and societal need.

Kubanek has held several previous leadership roles at Georgia Tech, including Associate Dean for Research in the College of Sciences and Associate Chair in the School of Biological Sciences. She joined the faculty at Georgia Tech in 2001. Her areas of research interest include chemical signaling among organisms (especially in aquatic systems), natural products chemistry, metabolomics, chemical biology, and drug discovery. She has authored approximately 100 research articles on marine plankton and coral reef chemical ecology, and on the discovery, mechanism of action, and biosynthesis of marine natural products. She was awarded the NSF CAREER Award in 2002, the Presidential Early Career Award for Scientists and Engineers (PECASE) in 2004, and was elected Fellow of the American Association for the Advancement of Science (AAAS) in 2012. In 2016, she served as chair of the Gordon Research Conference in Marine Natural Products; since 2016, she has chaired the Scientific Advisory Board of the Max Planck Institute for Chemical Ecology. Kubanek received her B.Sc. in Chemistry from Queen’s University, Canada, in 1991 and her Ph.D. in at the University of British Columbia in 1998, and performed postdoctoral research at the University of California – San Diego and the University of North Carolina at Wilmington.

Professor
Vice President of Interdisciplinary Research
Phone
404-894-8424
Office
ES&T 2242
Additional Research

All organisms use chemicals to assess their environment and to communicate with others. Chemical cues for defense, mating, habitat selection, and food tracking are crucial, widespread, and structurally and functionally diverse. Yet our knowledge of chemical signaling is patchy, especially in marine environments. In our research we ask, "How do marine organisms use chemicals to solve critical problems of competition, disease, predation, and reproduction?" Our group uses an integrated approach to understand how chemical cues function in ecological interactions, working from molecular to community levels. We also use ecological insights to guide discovery of novel pharmaceuticals and molecular probes. In collaboration with other scientists, our most significant scientific achievements to date are: 1) characterizing the unusual molecular structures of antimicrobial defenses that protect algae from pathogens and which show promise to treat human disease; 2) understanding that competition among single-celled algae (phytoplankton) is mediated by a complex interplay of chemical cues that affect harmful algal bloom dynamics; 3) unraveling the molecular modes of action of antimalarial natural products towards developing new treatments for drug-resistant infectious disease; 4) discovering that progesterone signaling and quorum sensing are key pathways in the alternating sexual and asexual reproductive strategy of microscopic invertebrate rotifers - animals whose evolutionary history was previously thought to preclude either cooperative behavior (quorum sensing) typically associated with bacteria and hormonal regulation via progesterone typically seen in vertebrates; 5) identifying a novel aversivechemoreception pathway in predatory fish thatresults inrapid recognition and rejectionofchemically defended foods, thereby protecting these foods (prey) from predators. Ongoing projects include: 1) Waterborne chemical cues in the marine plankton: a systems biology approach (including metabolomics); 2) Exploration, conservation, and development of marine biodiversity in Fiji and the Solomon Islands (including drug discovery, mechanisms of action, and chemical ecology); 3) The role of sensory environment and predator chemical signal properties in determining non-consumptive effect strength in cascading interactions on oyster reefs; 4) Regulation of red tide toxicity by chemical cues from marine zooplankton; 5) Chemoreception of prey chemical defenses on tropical coral reefs.

IRI/Group and Role
Bioengineering and Bioscience > Faculty
Data Engineering and Science > Faculty
Data Engineering and Science
Space > Faculty
University, College, and School/Department
Georgia Institute of Technology > College of Sciences > School of Biological Sciences

YongTae (Tony) Kim

YongTae (Tony) Kim's profile picture
yongtae.kim@me.gatech.edu

Kim joined the Woodruff School of Mechanical Engineering as an Assistant Professor in July 2013. Prior to his current appointment, he was a Postdoctoral Associate in the David H. Koch Institute for Integrative Cancer Research at MIT, where he developed biomimetic microsystems for probing nanoparticle behaviors in the inflamed endothelium and for synthesizing therapeutic and diagnostic nanomaterials. His doctorate research at CMU focused on closed-loop microfluidic control systems for lab-on-a-chip applications to biochemistry and developmental biology. Prior to his Ph.D., he was a researcher in areas of dynamics, controls, and robotics at R&D Divisions of Hyundai-Kia Motors and Samsung Electronics for six years.

Associate Professor, Woodruff School of Mechanical Engineering
Phone
404.385.1478
Office
Marcus 3134
Additional Research

Multifunctional Materials; Biosensors; Bio-MEMS; Tissue Engineering

IRI/Group and Role
Bioengineering and Bioscience > Faculty
Bioengineering and Bioscience
Matter and Systems > Affiliated Faculty
University, College, and School/Department
Georgia Institute of Technology > College of Engineering > Woodruff School of Mechanical Engineering

Yonggang Ke

Yonggang Ke's profile picture
yonggang.ke@emory.edu

Yonggang Ke's research is highly interdisciplinary combining chemistry, biology, physics, material science, and engineering. The overall mission of his research is to use interdisciplinary research tools to program nucleic-acid-based "beautiful structures and smart devices" at nanoscale, and use them for scientific exploration and technological applications. Specifically, his team focuses on (1) developing new DNA self-assembly paradigms for constructing DNA nanostructures with greater structural complexity, and with controllable sizes and shapes; (2) developing new imaging or drug delivery systems based on DNA nanostructuresl; (3) exploring design of novel DNA-based nanodevices for understanding basic biological questions at molecular level; (4) developing DNA-templated protein devices for constructing artificial bio-reactors.

For cancer-related research/application, Ke will focus on using DNA/RNA nanostructures as drug delivery vehicles. He is also interested in using DNA/RNA nanostructures to study cancer cell biology at molecular level.

Assistant Professor, Wallace H. Coulter Department of Biomedical Engineering
Phone
404.712.2712
Office
Emory HSRB E186
Additional Research

Molecular engineeringNucleic acid self-assemblyTargeted imaging and delivery

IRI/Group and Role
Bioengineering and Bioscience > Faculty
Bioengineering and Bioscience
University, College, and School/Department
Georgia Institute of Technology > College of Engineering > Coulter Department of Biomedical Engineering

Ravi Kane

Ravi Kane's profile picture
ravi.kane@chbe.gatech.edu

Ravi Kane is the Garry Betty/V Foundation Chair and GRA Eminent Scholar in Cancer Nanotechnology. He received a B.S. in Chemical Engineering from Stanford University in 1993. Also, he received an M.S. in Chemical Engineering Practice and a Ph.D. in Chemical Engineering from MIT, working with Bob Cohen and Bob Silbey. After postdoctoral research with George Whitesides in the Department of Chemistry and Chemical Biology at Harvard University, he joined Rensselaer Polytechnic Institute (RPI) as an assistant professor in 2001. He was promoted to associate professor in 2006, to full professor in 2007, and to the P.K. Lashmet Professor in 2008. He served as the head of RPI’s Howard P. Isermann Department of Chemical and Biological Engineering before moving to Georgia Tech in 2015. Prof. Kane has graduated 27 Ph.D students and contributed to over 130 scientific publications.

Professor
Garry Betty/V Foundation Chair
Georgia Research Alliance Eminent Scholar in Cancer Nanotechnology
Phone
404-385-4608
Office
EBB 5019
Additional Research

Professor Kane's groupconducts research at the interface of biotechnology and nanotechnology.The group is designing nanoscale polyvalent therapeutics and working on the molecular engineering of biosurfaces and nanostructures. A major focus of the group's research involves the design of polyvalent ligands, i.e., nanoscale scaffolds presenting multiple copies of selected biomolecules.The Kane group has made seminal contributions to a fundamental understanding of polyvalent recognition and has designed polyvalent inhibitors that are effectivein vivo.Currently, the group is designing polyvalent molecules that control stem cell fate as well as polyvalent inhibitors of pathogens such as HIV and influenza.The group is also designing nanoscale scaffolds for antigen presentation as part of novel strategies for designing vaccines.The approach could lead to the development of "universal" influenza vaccines as well as effective vaccines targeting RSV and malaria.Other interests of the group involve optogenetics — the development and application of methods that use light to control cell function — as well as the design of enzymes and nanocomposites that target antibiotic-resistant pathogens.

IRI/Group and Role
Bioengineering and Bioscience > Faculty
Bioengineering and Bioscience > Faculty Steering Committee
University, College, and School/Department
Georgia Institute of Technology > College of Engineering > School of Chemical and Biomolecular Engineering

Seung Soon Jang

Seung Soon Jang's profile picture
SeungSoon@mse.gatech.edu

Seung Soon Jang joined the School of Materials Science and Engineering at the Georgia Institute of Technology in July 2007. Jang worked at Samsung Electronics and the Materials and Process Simulation Center (MSC) at CalTech performing various researches in nanoelectronics, fuel cell, and interfacial systems as a director of Supramolecular Technology for six years.

His research interest includes computations and theories to characterize and design nanoscale systems based on the molecular architecture-property relationship, which are especially relevant to molecular electronics, molecular machines, fuel cell technology and biotechnology.

Professor, School of Materials Science and Engineering
Director, Computational NanoBio Technology Lab
Phone
404.385.3356
Office
Love 351
Additional Research

Jang's research interest is to characterize and design nanoscale systems based on the molecular architecture-property relationship using computations and theories, which are especially relevant to designing new biomaterials for drug delivery and tissue engineering. Currently, he is focusing on 1) NanoBio-mechanics for DNA, lipid bilayer, and hydrogel systems; 2) Molecular interaction of Alzheimer proteins with various small molecules. Dr. Jang is also interested in various topics such as nanoelectronics, nanostructured energy technologies for fuel cell, battery and photovoltaic devices.;Computational mechanics; Nanostructured Materials; Polymeric composites; Biomaterials; Fuel Cells; Delivery and Storage

IRI/Group and Role
Bioengineering and Bioscience > Faculty
Energy > Hydrogen Group
Energy > Research Community
Bioengineering and Bioscience
Energy
University, College, and School/Department
Georgia Institute of Technology > College of Engineering > School of Materials Science Engineering
Research Areas
Energy
  • Fuels
  • Advanced Manufacturing for Energy

Karl Jacob

Karl Jacob's profile picture
karl.jacob@mse.gatech.edu

Karl I. Jacob, a professor of Materials Science and Engineering with a joint appointment in the G. W. Woodruff School of Mechanical Engineering, teaches graduate and undergraduate courses on polymer physics and engineering, rheology, and mechanics of polymeric materials. His graduate work was in the area of numerical analysis of vibrating three-dimensional structures. He came to Georgia Tech from DuPont Corporation in 1995. His initial work at the DuPont Dacron Research Laboratory was in the area of fiber-reinforced composite materials and in the development and modeling of fiber spinning processes. He then moved to the DuPont Central Research and Development Department, where he was involved in molecular modeling, computational chemistry, and diffusion.

Jacob is a member of the American Academy of Mechanics, the American Society of Mechanical Engineers, the Sigma Xi Research Society, and the Phi Kappa Phi Honor Society.

Professor, School of Materials Science and Engineering and School of Mechanical Engineering
Phone
404.894.2541
Office
MRDC-1 4509
Additional Research

"Dr. Jacob's research is directed at stress induced phase changes, nanoscale characterization of materials, synthesis of polymeric nanofibers, mechanical behavior of fiber assemblies (particularly related to biological systems and biomimitic systems), nanoparticle reinforced composites, transdermal drug delivery systems, large scale deformation of rubbery (networked) polymers, and nanoscale fracture of materials. The objectives in this work, using theoretical, computational and experimental techniques, is to understand the effect of micro- and nano- structures in the behavior of materials in order to try to design the micro/nano structures for specific materials response. Dr. Jacob plans are to continue current research interests with a multidisciplinary thrust with more emphasis in bio related areas and to start some work on the dynamic behavior of materials and structures. Graduate students could benefit from the interdisciplinary nature of the work combining classical continuum mechanics with nanoscale analysis for various applications, particularly in the nano and bio areas. Dr. Jacob has extensive experience in vibrations and stability of structures, mechanics of polymeric materials, behavior of fiber assemblies, stress-induced phase transformation, diffusion, and molecular modeling. His research involves the application of mechanics principles, both theoretical and experimental, in the analysis and design of materials for various applications.";Fibers; smart textiles; fuel cells; Polymeric composites

IRI/Group and Role
Bioengineering and Bioscience > Faculty
Renewable Bioproducts > Affiliated Faculty
People and Technology
Bioengineering and Bioscience
University, College, and School/Department
Georgia Institute of Technology > College of Engineering
Research Areas
Renewable Bioproducts
  • Circular Materials

Nicholas V. Hud

Nicholas V. Hud's profile picture
nick.hud@chemistry.gatech.edu

Nicholas Hud was born and raised in Los Angeles, California. He received his B.S. degree in physics from Loyola Marymount University. His Ph.D. was conferred by the University of California, Davis for physical investigations of DNA condensation by protamine. From 1992-1995 he was a postdoctoral fellow in the biology and biotechnology research program at Lawrence Livermore National Laboratory with Rod Balhorn. From 1995-1998 he was an NIH postdoctoral fellow in the Molecular Biology Institute at UCLA where he worked with Juli Feigon and Frank A. L. Anet on the application of NMR spectroscopy to the study of DNA-cation interactions. Hud joined the faculty at Georgia Tech as an assistant professor in 1999 and was promoted to full professor in 2008. He has been visiting professor of chemistry at the National NMR Center in Slovenia, and at Imperial College London. Hud currently serves as PI of the NSF Center for Chemical Evolution, as chair of the biochemistry division of the School of Chemistry and Biochemistry, as co-director of the Georgia Tech-Emory University Center for Fundamental and Applied Molecular Evolution (FAME), and as associate director of the Petit Institute for Bioengineering and Bioscience.

Associate Director, Parker H. Petit Institute for Bioengineering and Bioscience
Regents’ Professor of Chemistry & Biochemistry
Director, NSF Center for Chemical Evolution
Phone
404-385-1162
Office
Petit Biotechnology Building, Office 1108
Additional Research

Intercalation-mediated Nucleic Acid Assembly, The Molecular Midwife & the Origin of Life, Nucleic Acid-Cation Interactions, Understanding DNA & RNA Condensation. The research in our laboratory is directed towards elucidating the fundamental chemical and physical principles that govern nucleic acid (RNA and DNA) assembly. We are interested in how the physical properties of nucleic acids govern biological functions in contemporary life, and how these same properties provide clues to the origin and early evolution of life. We are also applying our knowledge of nucleic acids to problems that are of current importance in medicine and biotechnology. Specific projects include investigations of: 1) the origin and evolution of RNA; 2) cation, solvent and small molecule interactions with nucleic acids; 3) nucleic acid condensation and packaging; and 4) folding and evolution of the ribosome. Our research involves the application of a wide variety of physical and chemical techniques.

IRI/Group and Role
Bioengineering and Bioscience > Leadership, Faculty
Bioengineering and Bioscience > Faculty Steering Committee
University, College, and School/Department
Georgia Institute of Technology > College of Sciences > School of Chemistry & Biochemistry

Robert Guldberg

Robert Guldberg's profile picture
robert.guldberg@me.gatech.edu

Robert E. Guldberg is the DeArmond Executive Director of the Phil and Penny Knight Campus for Accelerating Scientific Impact and Vice President of the University of Oregon. Guldberg’s research is focused on musculoskeletal mechanobiology, regenerative medicine, and orthopaedic medical devices. Over his 25+ year academic career, Dr. Guldberg has produced over 280 peer-reviewed publications, served as an advisor and board member for numerous biotechnology companies, and co-founded six start-ups. He was previously executive director of the Parker H. Petit Institute for Bioengineering and Bioscience at Georgia Tech from 2009-2018. In 2018, he was selected from a national search to lead the Knight Campus as its inaugural permanent Executive Director, where he has led the creation of its strategic plan, hired faculty into the campus’ first building opened in 2020, and launched the University of Oregon’s first ever engineering degree program. In 2021, he led the launch of Phase 2 of the Knight Campus development with the announcement of a second $500 million gift from Phil and Penny Knight. At the national level, Dr. Guldberg is past Chair of the Americas Chapter of the Tissue Engineering and Regenerative Medicine International Society (TERMIS-AM). He currently serves on the Executive Leadership Council of the Wu Tsai Human Performance Alliance, a $220 million global initiative to promote wellness and peak performance through scientific discovery and innovation. Dr. Guldberg is an elected fellow of TERMIS, the American Society of Mechanical Engineers (ASME), the American Institute for Medical and Biological Engineering (AIMBE), the Orthopaedic Research Society (ORS), and the National Academy of Inventors (NAI).

Vice President and Robert and Leona DeArmond Executive Director
Adjunct Professor
Phone
541-346-3110
Additional Research
Guldberg's research interests focus on musculoskeletal growth and development, functional regeneration following traumatic injury, and degenerative diseases, including skeletal fragility and osteoarthritis. His research is supported by the NIH, NSF, DoD, and several biotechnology companies and has resulted in over 150 book chapters and publications. Guldberg is a Fellow of the American Institute for Medical and Biological Engineering (AIMBE) and holds several national leadership positions.
IRI/Group and Role
Bioengineering and Bioscience > Faculty
Bioengineering and Bioscience
University, College, and School/Department
University of Oregon > Phil and Penny Knight Campus for Accelerating Scientific Impact
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